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Monitor Intently (1)phenobarbital will lower the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Contraindicated (one)phenobarbital will lessen the level or effect of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals shouldn't select estradiol valerate/d